IT2-H52W4
Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Cannot supply to this region.
- SKU:
- IT2-H52W4
- Additional Names:
- Integrin alpha M beta 2|ITGAM&ITGB2
- Physical State:
- Powder
- Molecular Weight:
- 127.2 kDa (ITGAM) & 80.2 kDa (ITGB2)
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Immunogen:
- Integrin alpha M beta 2
- Species:
- Human
- Uniprot:
- P05107-1, P11215-2
- Synonyms:
- CD11 antigen-like family member B;Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta;Cell surface glycoprotein MAC-1 subunit alpha;Complement receptor C3 subunit beta;CR-3 alpha chain;Leukocyte adhesion receptor MO1;Neutrophil adherence receptor
- Extra Details:
- Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
- Shipping Conditions:
- Ambient