Rat Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free

Cannot supply to this region.

SKU:: IT1-R52W9
Additional Names:: Integrin alpha 2 beta 1|ITGA2 & ITGB1
Physical State:: Powder
Molecular Weight:: 127.6 kDa (ITGA2) & 83.7 kDa (ITGB1)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, pH8.0
Immunogen:: Integrin alpha 2 beta 1
Species:: Rat
Uniprot:: A0A0G2K470-1, P49134-1
Synonyms:: Beta oligodendroglia;Fibronectin receptor subunit beta;VLA-4 subunit beta
Extra Details:: Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.