Biotinylated Human Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His,Avitag[TM]&Tag Free

Cannot supply to this region.

SKU:: IT1-H82W7
Physical State:: Powder
Molecular Weight:: 130 kDa (ITGA2) (E534K) & 83.7 kDa (ITGB1) (E534K)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Integrin alpha 2 beta 1
Species:: Human
Uniprot:: P05556-1, P17301-1
Synonyms:: CD49 antigen-like family member B;Collagen receptor;Fibronectin receptor subunit beta;Glycoprotein IIa;Platelet membrane glycoprotein Ia;VLA-2 subunit alpha;VLA-4 subunit beta
Extra Details:: Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.