Human ITPRIPL1 Protein, His Tag

Cannot supply to this region.

SKU:: IT1-H52H3
Physical State:: Powder
Molecular Weight:: 11.2 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: ITPRIPL1
Species:: Human
Uniprot:: Q6GPH6
Synonyms:: inositol 1,4,5-triphosphate receptor-interacting protein-like 1;inositol 1,4,5-trisphosphate receptor interacting protein-like 1;inositol 1,4,5-trisphosphate receptor-interacting protein-like 1;KIAA1754L
Extra Details:: Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 E Epsilon, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.