ILR-M5251
Mouse IL-23 R Protein, Fc Tag (BLI verified)
Cannot supply to this region.
- SKU:
- ILR-M5251
- Additional Names:
- IL-23 R|IL-23 Receptor
- Physical State:
- Powder
- Molecular Weight:
- 66.8 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- IL-23 R
- Species:
- Mouse
- Uniprot:
- Q8K4B4-1
- Extra Details:
- Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
- Shipping Conditions:
- Ambient