Biotinylated Human IL-10 R alpha / CD210 Protein, Fc,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: ILR-H82F6
Additional Names:: CD210|CDw210a|IL-10 receptor subunit alpha|IL-10R subunit 1|IL-10R subunit alpha|IL-10R1|IL-10RA|IL10R|IL10RA|Interleukin-10 receptor subunit 1|Interleukin-10 receptor subunit alpha
Physical State:: Powder
Molecular Weight:: 52.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Immunogen:: IL-10 R alpha
Species:: Human
Uniprot:: Q13651-1
Synonyms:: CDw210a;Interleukin-10 receptor subunit 1
Extra Details:: Interleukin-10 receptor subunit alpha (IL-10 R alpha ) is a cell surface receptor for the cytokine IL-10 that participates in IL-10 mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.