Biotinylated Human IL-28 R alpha Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: ILR-H82E4
Physical State:: Powder
Molecular Weight:: 27.2 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-28 R alpha
Species:: Human
Uniprot:: Q8IU57-1
Synonyms:: Cytokine receptor class-II member 12;Cytokine receptor family 2 member 12;Interleukin-28 receptor subunit alpha;Likely interleukin or cytokine receptor 2
Extra Details:: IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.