ILR-H52H9
Human IL-28 R alpha / IFN-lambda R1 Protein, His Tag
Cannot supply to this region.
- SKU:
- ILR-H52H9
- Additional Names:
- CRF2-12|Cytokine receptor class-II member 12|Cytokine receptor family 2 member 12|IFN-lambda receptor 1|IFN-lambda-R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|Interferon lambda receptor 1|Interleukin-28 receptor subunit alpha|Likely interleukin o
- Physical State:
- Powder
- Molecular Weight:
- 25.5 kda
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- IL-28 R alpha
- Species:
- Human
- Uniprot:
- Q8IU57-1
- Synonyms:
- Cytokine receptor class-II member 12;Cytokine receptor family 2 member 12;Interleukin-28 receptor subunit alpha;Likely interleukin or cytokine receptor 2
- Extra Details:
- IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.
- Shipping Conditions:
- Ambient