Human IL-1 RI Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: ILI-H5253
Physical State:: Powder
Molecular Weight:: 63.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-1 RI
Species:: Human
Uniprot:: P14778
Synonyms:: CD121 antigen-like family member A;CD121A;D2S1473;IL-1R-1;IL-1R-alpha;IL-1RT-1;IL-1RT1;IL1R;IL1RA;interleukin 1 receptor alpha, type I;interleukin-1 receptor alpha;interleukin-1 receptor type 1;interleukin-1 receptor type I;P80
Extra Details:: IL1R1 also know as Interleukin-1 receptor type 1, is the receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells