ILC-H5257
Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
Cannot supply to this region.
- SKU:
- ILC-H5257
- Additional Names:
- CD217 & IL-17 RC|IL-17 RA & IL-17 RC|IL-17RA & IL-17RC
- Physical State:
- Powder
- Molecular Weight:
- 60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC)
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- IL-17 RA & IL-17 RC
- Species:
- Human
- Uniprot:
- Q96F46-1
- Synonyms:
- CDw217
- Extra Details:
- Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
- Shipping Conditions:
- Ambient