Rabbit IL-23 alpha & IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)

Cannot supply to this region.

SKU:: ILB-R52W4
Physical State:: Powder
Molecular Weight:: 21.0 kDa & 34.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL23A & IL12B
Species:: Rabbit
Extra Details:: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.