Biotinylated Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, His,Avitag[TM]&Tag Free (MALS verified)

Cannot supply to this region.

SKU:: ILB-M82W3
Physical State:: Powder
Molecular Weight:: 23.2 kDa & 35.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL23A & IL12B
Species:: Mouse
Uniprot:: P43432, Q9EQ14
Synonyms:: CLMF p40;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-;Il-1;Il-12;IL-12 p40 subunit;IL-12 subunit p40;Il-12b;Il-12p40;IL-23;IL-23 subunit alpha;IL-23 subunit p40;IL-23-A;IL-23p19;Il12p40;interleukin-12 p40 subunit;interleukin-12 subunit beta;interleukin-23 subunit alpha;interleukin-23 subunit p19;p1;p19;p40
Extra Details:: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.