Mouse IL-12 R beta 2 Protein, His Tag (SPR verified)

Cannot supply to this region.

SKU:: ILB-M52H3
Physical State:: Powder
Molecular Weight:: 70.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-12 R beta 2
Species:: Mouse
Uniprot:: P97378
Synonyms:: A930027I18Rik;If;Ifnm;IL-12;IL-12 receptor subunit beta-2;IL-12R subunit beta-2;IL-12RB2;interferon response to microorganisms;interleukin-12 receptor subunit beta-2
Extra Details:: The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas, IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.