Human IL-17B Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: ILB-H5257
Additional Names:: Cytokine Zcyto7|IL-20|IL17B|IL20|Interleukin-17B|Interleukin-20|Neuronal interleukin-17-related factor|NIRF|ZCYTO7
Physical State:: Powder
Molecular Weight:: 44.6 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-17B
Species:: Human
Uniprot:: Q9UHF5-1
Synonyms:: Cytokine Zcyto7;Interleukin-20;Neuronal interleukin-17-related factor
Extra Details:: IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-A Alpha effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA- IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.