Golden Hamster IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: ILB-G52W4
Physical State:: Powder
Molecular Weight:: 21.6 kDa (IL23A) & 34.8 kDa (IL12B)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL23A & IL12B
Species:: Hamster
Uniprot:: Q8CJE6
Synonyms:: CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;IL-12B;IL-12p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 p40 subunit;interleukin-12 subunit beta;interleukin-12p40
Extra Details:: Interleukin-23 subunit alpha (IL-23A) can associate with interleukin-12 subunit beta (IL-12B) to form IL-23, a heterodimeric cytokine that functions in innate and adaptive immunity. IL-23 promotes the production of IL-17, and together they contribute to acute responses to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JAK-STAT signaling cascade, stimulates memory T-cells rather than naive T-cells, and promotes the production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may play a key role in autoimmune inflammatory diseases; it may also promote tumorigenesis in certain inflammatory contexts.