Guinea pig IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)

Cannot supply to this region.

SKU:: ILB-G52W3
Physical State:: Powder
Molecular Weight:: 20.7 kDa (IL23A) & 35.2 kDa (IL12B)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL23A & IL12B
Species:: Guinea Pig
Uniprot:: Q6LA37, Q924V5
Synonyms:: CLMF p40;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 p40;IL-12 subunit p40;IL-12B;IL-23 p19 subunit;IL-23 subunit alpha;IL-23-A;IL-23p19;interleukin-12 p40 subunit;interleukin-12 subunit beta;Interleukin-23 p19 subunit;interleukin-23 subunit alpha;interleukin-23 subunit p19
Extra Details:: Interleukin-23 subunit alpha (IL-23A) can associate with interleukin-12 subunit beta (IL-12B) to form IL-23, a heterodimeric cytokine that functions in innate and adaptive immunity. IL-23 promotes the production of IL-17, and together they contribute to acute responses to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JAK-STAT signaling cascade, stimulates memory T-cells rather than naive T-cells, and promotes the production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may play a key role in autoimmune inflammatory diseases; it may also promote tumorigenesis in certain inflammatory contexts.