Biotinylated Mouse IL-2 R alpha / CD25 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: ILA-M82E9
Physical State:: Powder
Molecular Weight:: 28.3 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-2 R alpha
Species:: Mouse
Uniprot:: P01590
Synonyms:: CD25;I;IL-2 receptor subunit alpha;IL-2-RA;IL-2R alpha chain;IL-2R subunit alpha;IL2-RA;Il2r;interleukin-2 receptor subunit alpha;Ly-4;Ly-43;p55;p55 chain
Extra Details:: Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.