Mouse IL-1 alpha / IL-1F1 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: ILA-M5213
Additional Names:: IL-1 ALPHA|IL1A|IL1F1|IL1A Alpha
Physical State:: Powder
Molecular Weight:: 19.9 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-1 alpha
Species:: Mouse
Uniprot:: P01582-1
Extra Details:: Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1A Alpha is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1A Alpha precursor by healthy epidermal keratinocytes interfere with the important role of IL-1A Alpha in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1A Alpha possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1A Alpha activates a set of immune system response processes.