Human IL-36 gamma / IL-1F9 Protein, Tag Free (MALS verified)

Cannot supply to this region.

SKU:: IL9-H5115
Physical State:: Powder
Molecular Weight:: 17.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-36 gamma
Species:: Human
Uniprot:: Q9NZH8-1
Synonyms:: IL-1-related protein 2;Interleukin-1 epsilon;Interleukin-1 family member 9;Interleukin-1 homolog 1
Extra Details:: The IL-36 subfamily of cytokines is the most diverse, including three agonists(IL-36A Alpha, IL-36B Beta, and IL-36), one antagonist(IL-36Ra), one cognate receptor(IL-36R) and one accessory protein(IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. IL-36 that binds to and signals through the IL-36R which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Appropriately balanced IL-36 signaling is a critical determinant of skin and lung health.