Human IL-13 R alpha 1 & IL-13 Protein, Tag Free&His Tag (MALS verified)

Cannot supply to this region.

SKU:: IL3-H52W3
Physical State:: Powder
Molecular Weight:: 42.2 kDa (IL13RA1) & 19.0 kDa (IL13)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-13 R alpha 1 & IL-13
Species:: Human
Uniprot:: P35225, P78552-1
Synonyms:: Cancer/testis antigen 19;IL-13;interleukin-13;P600
Extra Details:: Interleukin-13 (IL-13) is a pleiotropic cytokine produced predominantly by T helper 2 (Th2) cells, mast cells, basophils, and group 2 innate lymphoid cells (ILC2s). IL-13 binds to the IL-13RA Alpha1 subunit with low-to-moderate affinity to form an initial binary complex. This binary complex subsequently recruits the shared IL-4RA Alpha chain to form a high-affinity heterodimeric Type II receptor complex (IL-4RA Alpha/IL-13RA Alpha1). The functional dimer triggers downstream intracellular signaling, primarily through the JAK/STAT6 pathway. IL-13 plays a central role in type 2 immune responses, driving IgE synthesis, goblet cell metaplasia, mucus overproduction, smooth muscle contraction, and tissue fibrosis. It is a critical driver of allergic diseases such as asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis.