Human IL-3 Protein, His Tag (MALS & BLI verified)

Cannot supply to this region.

SKU:: IL3-H52H9
Additional Names:: IL3|Interleukin-3|MCGF|MGC79398|MGC79399|MULTI-CSF
Physical State:: Powder
Molecular Weight:: 17.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-3
Species:: Human
Uniprot:: P08700-1
Synonyms:: Hematopoietic growth factor;Mast cell growth factor;Multipotential colony-stimulating factor;P-cell-stimulating factor
Extra Details:: Interleukin 3 is also known as IL-3, is a protein that in humans is encoded by the IL3 gene. Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. The IL-3 receptor is a heterodimer of the IL-3 specific A Alpha-chain and the common B Beta-chain, B Betac, which is also used by GM-CSF and IL-5. [3] Binding of IL-3 can also involve substitution of the B Betac by a B BetaIL-3-chain that appears to be specific for IL-3 . Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats, and the PI3K/Akt pathway. IL-3 may play an important role in the development of airway inflammation associated with asthma. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.