IL3-H51H3
Human IL-33 (2-270) Protein, His Tag
Cannot supply to this region.
- SKU:
- IL3-H51H3
- Physical State:
- Liquid
- Molecular Weight:
- 32.6 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS, Arginine, pH7.4
- Immunogen:
- IL-33
- Species:
- Human
- Uniprot:
- O95760-1
- Synonyms:
- Interleukin-1 family member 11;Nuclear factor from high endothelial venules
- Extra Details:
- Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-K KappaB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
- Shipping Conditions:
- Dry Ice