IL2-M52H7
Mouse IL-13 R alpha 2 Protein, His Tag (MALS verified)
Cannot supply to this region.
- SKU:
- IL2-M52H7
- Physical State:
- Powder
- Molecular Weight:
- 38.3 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- IL-13 R alpha 2
- Species:
- Mouse
- Uniprot:
- O88786
- Synonyms:
- CD213a;CD213a2;IL-13R-alpha-2;interleukin-13 receptor subunit alpha-2
- Extra Details:
- Interleukin-13 receptor subunit alpha-2 is also known as IL13RA Alpha2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13RA Alpha2 is closely related to IL13RA Alpha1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13RA Alpha2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13RA Alpha1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13RA Alpha2 and the IL4RA Alpha chain. In spite of the failed STAT signaling function, IL13RA Alpha2 dose induce TGF-beta production and fibrosis. Additionally, IL13RA Alpha2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
- Shipping Conditions:
- Ambient