IL2-H5213
Human IL-12 Protein, Research Grade
Cannot supply to this region.
- SKU:
- IL2-H5213
- Physical State:
- Powder
- Molecular Weight:
- 58.9 kda
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- IL-12B & IL-12A
- Species:
- Human
- Uniprot:
- P29459-1, P29460-1
- Synonyms:
- Cytotoxic lymphocyte maturation factor 35 kDa subunit;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p35;IL-12 subunit p40;NK cell stimulatory factor chain 1;NK cell stimulatory factor chain 2
- Extra Details:
- IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL-12, produced by macrophages in response to infectious agents, is a central mediator of the cell-mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS.
- Shipping Conditions:
- Ambient