Human IL-31 Protein, His Tag, low Endotoxin (MALS verified)

Cannot supply to this region.

SKU:: IL1-H5247
Additional Names:: IL-31|IL31|Interleukin-31
Physical State:: Powder
Molecular Weight:: 17.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IL-31
Species:: Human
Uniprot:: Q6EBC2-1
Extra Details:: IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor B Beta (OSMRB Beta) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.