Mouse IGF-I R / IGF-1 R Protein, Fc Tag

Cannot supply to this region.

SKU:: IGR-M5253
Physical State:: Powder
Molecular Weight:: 130.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IGF-I R / IGF-1 R
Species:: Mouse
Uniprot:: Q60751-1
Synonyms:: Insulin-like growth factor I receptor
Extra Details:: The Insulin-like Growth Factor 1 Receptor (IGF1R) is also known as CD221 and JTK13, and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide hormone similar in molecular structure to insulin. IGF1R is made up of two A Alpha subunits and two B Beta subunits. Both the A Alpha and B Beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by disulfide bonds to form a functional transmembrane A AlphaB Beta chain. The A Alpha chains are located extracellularly, while the B Beta subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R has a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is 60% sequence homology between IGF1R and the insulin receptor. In response to ligand binding, the A Alpha chains induce the tyrosine autophosphorylation of the B Beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.

Shipping Conditions:: Ambient