IGR-M5223
Mouse IGF-I R / IGF-1 R Protein, His Tag
Cannot supply to this region.
- SKU:
- IGR-M5223
- Additional Names:
- CD221|IGF1R|IGFR|JTK13|MGC142170|MGC142172|MGC18216
- Physical State:
- Powder
- Molecular Weight:
- 81.7 kDa, 24.3 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- IGF-I R / IGF-1 R
- Species:
- Mouse
- Uniprot:
- Q60751-1
- Synonyms:
- Insulin-like growth factor I receptor
- Extra Details:
- The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the A Alpha and B Beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane A AlphaB Beta chain.The A Alpha chains are located extracellularly while the B Beta subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the A Alpha chains induce the tyrosine autophosphorylation of the B Beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
- Shipping Conditions:
- Ambient