Human IgG2 Fc Protein, Tag Free (MALS & SPR verified)

Cannot supply to this region.

SKU:: IG2-H5206
Additional Names:: IGHG2
Physical State:: Powder
Molecular Weight:: 25.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: IgG2 Fc
Species:: Human
Uniprot:: P01859-1
Synonyms:: Ig gamma-2 chain C region;Ig gamma-2 chain C region DOT;Ig gamma-2 chain C region TIL;Ig gamma-2 chain C region ZIE
Extra Details:: Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-G Gamma (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).