Human HVEM / TNFRSF14 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: HVM-H52E9
Additional Names:: ATAR|CD270|HVEA|HVEM|LIGHTR|TNFRSF14|TR2
Physical State:: Powder
Molecular Weight:: 19.2 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: HVEM
Species:: Human
Uniprot:: Q92956-1
Synonyms:: Herpes virus entry mediator A;Tumor necrosis factor receptor-like 2
Extra Details:: Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFB Beta (lymphotoxin A Alpha) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTB BetaR, the receptor for lymphotoxin A AlphaB Beta heterotrimer. The role of the HVEM LIGHT /LTB Beta receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.