Monoclonal Anti-HRSV F Antibody, Human IgG1 (AM14) (MALS verified)

Cannot supply to this region.

SKU:: HRF-S367
Physical State:: Powder
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Reactivities:: Mouse
Buffer:: PBS (pH 7.4)
Immunogen:: Prefusion glycoprotein F0/pre-F protein (RSV)
Clone:: AM14
Extra Details:: Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. The RSV fusion glycoprotein (RSV F) is the principal target of RSV neutralizing antibodies in human sera. The RSV F is a type I viral fusion protein synthesized as inactive, single-chain polypeptides that assemble into trimers. RSV F fuses the viral and host cell membranes by irreversible protein refolding from the labile prefusion conformation to the stable post-fusion conformation. Antibody AM14 has a uniquely trimer-specific and and neutralizing activity. It recognizes a quaternary epitope that spans two protomers and includes a region that undergoes extensive conformational changes in the pre- to postfusion F transition. The specificity of the potent RSV neutralizing antibody AM14 makes it a useful reagent for probing or isolating the cleaved trimeric state of prefusion F.