HLM-H82EA
Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*15:01&MBP (ENPVVHFFKNIVTPR) Complex Protein (Monomer, MALS verified)
Cannot supply to this region.
- SKU:
- HLM-H82EA
- Physical State:
- Powder
- Molecular Weight:
- 29.8 kDa and 29.2 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- HLA-DRA1*0101 & HLA-DRB1*1501 & MBP(ENPVVHFFKNIVTPR)
- Species:
- Human
- Extra Details:
- The peptide ENPVVHFFKNIVTPR, derived from myelin basic protein (MBP), is presented by the MHC class II heterodimer HLA-DRA1*01:01/HLA-DRB1*15:01. This specific peptide-MHC II complex is a predominant autoantigen target in multiple sclerosis (MS) and is strongly associated with the HLA-DRB1*15:01 genetic risk allele. Its recognition by autoreactive CD4⁺ T helper cells initiates and drives the inflammatory immune response against the myelin sheath in the central nervous system, making it a prototypical complex for studying autoimmune demyelination and MS pathogenesis.
- Shipping Conditions:
- Ambient