HL5-H82E6
Biotinylated Human HLA-DRA1*01:01&HLA-DRB1*04:01&GAD65 (NFFRMVISNPAAT) Complex Protein (Monomer, MALS verified)
Cannot supply to this region.
- SKU:
- HL5-H82E6
- Physical State:
- Powder
- Molecular Weight:
- 29.6 kDa and 29.2 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- HLA-DRA1*0101 & HLA-DRB1*0401 & GAD65 (NFFRMVISNPAAT)
- Species:
- Human
- Extra Details:
- The peptide NFFRMVISNPAAT, derived from the human autoantigen glutamic acid decarboxylase 65 (GAD65), is presented by the MHC class II molecule HLA-DRA1*01:01/HLA-DRB1*04:01. This specific peptide-MHC II complex is strongly associated with the genetic risk for type 1 diabetes (T1D), particularly in individuals carrying the HLA-DRB1*04:01 allele. Recognition of this complex by autoreactive CD4⁺ T cells is a pivotal event in the autoimmune attack against pancreatic islet beta cells, making it a critical target for understanding the etiology of T1D and for developing antigen-specific immunotherapies.
- Shipping Conditions:
- Ambient