H2B-M82E3
Biotinylated Mouse H-2Kd&B2M&InsB (LYLVCGERL) Complex Protein (Monomer, MALS verified)
Cannot supply to this region.
- SKU:
- H2B-M82E3
- Physical State:
- Powder
- Molecular Weight:
- 40.0 kDa and 15.6 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- H-2Kd & B2M & InsB (LYLVCGERL)
- Species:
- Mouse
- Uniprot:
- P01887, P01902
- Synonyms:
- beta-2-microglobulin;beta2-;beta2-m;beta2m;Ly-m1;Ly-m11
- Extra Details:
- The peptide LYLVCGERL, derived from mouse insulin B chain (InsB), is presented by the H-2Kd/B Beta2-microglobulin (B Beta2m) complex. This complex is a central autoantigen in the non-obese diabetic (NOD) mouse model of type 1 diabetes. Recognition of this peptide-MHC complex by autoreactive CD8⁺ T cells is a critical early event in the destruction of insulin-producing pancreatic beta cells, making it a fundamental target for studying autoimmune diabetes pathogenesis and tolerance mechanisms.
- Shipping Conditions:
- Ambient