Human Granzyme B Protein, Tag Free (active enzyme)

Cannot supply to this region.

SKU:: GZB-H5213
Physical State:: Liquid
Molecular Weight:: 25.5 kda
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: Granzyme B
Species:: Human
Uniprot:: P10144
Synonyms:: C11;cathepsin G-like 1;CCPI;CGL-1;CGL1;CSP-B;CSPB;CTLA-1;CTLA1;CTSGL1;cytotoxic serine protease B;cytotoxic T-lymphocyte proteinase 2;fragmentin 2;Fragmentin-2;granzyme B;granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1);Granzyme-2;HLP;human lymphocyte protein;SECT;T-cell serine protease 1-3E
Extra Details:: Granzyme B (GZMB) is a cytosolic protease abundant in cytotoxic T-cells and natural killer cells, pivotal for immune defense. Delivered into target cells, GZMB activates caspase-independent pyroptosis by cleaving gasdermin-E (GSDME). This triggers pyroptosis, leading to target cell death. GZMB exhibits substrate specificity for aspartate residue cleavage and contributes to an activation cascade of caspases, impacting apoptosis execution. Involved in bacterial infection response, GZMB cleaves and activates caspase-7, promoting plasma membrane repair. Its multifaceted activities underscore its crucial role in immune responses and cellular defense.