Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: GUC-H82E9
Additional Names:: GC-C|GUC2C|GUCY2C|hSTAR|STA receptor|STAR
Physical State:: Powder
Molecular Weight:: 49.6 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: GUCY2C
Species:: Human
Uniprot:: P25092-1
Synonyms:: Guanylyl cyclase C;Intestinal guanylate cyclase
Extra Details:: GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.