GP2-H5255
Human Glypican 2 / GPC2 Protein, Fc Tag (SPR verified)
Cannot supply to this region.
- SKU:
- GP2-H5255
- Additional Names:
- Glypican 2|GPC2
- Physical State:
- Powder
- Molecular Weight:
- 84.6 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- Tris with Glycine, Arginine and NaCl, pH7.5
- Immunogen:
- Glypican 2
- Species:
- Human
- Uniprot:
- Q8N158-1
- Extra Details:
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/B Beta-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Shipping Conditions:
- Ambient