HIV-1 (HXB2) GP41 Pre-hairpin intermediate Protein, His Tag

Cannot supply to this region.

SKU:: GP1-H51H3
Physical State:: Liquid
Molecular Weight:: 44.3 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM HEPES, 150 mM NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Immunogen:: Envelope glycoprotein gp41/gp41 (HIV)
Species:: Virus
Uniprot:: P04578
Synonyms:: Env polyprotein;Envelope surface glycoprotein gp160, precursor;HIV1gp8
Extra Details:: Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41. gp120 directs virion attachment to the cell-surface receptors, and gp41 then promotes viral-cell membrane fusion. A soluble, alpha-helical, trimeric complex within gp41 composed of N-terminal and C-terminal extraviral segments has been proposed to represent the core of th e fusion-active conformation of the HIV-1 envelope. Three N-terminal helices within the bundle form a central, parallel, trimeric coiled coil, whereas three C-terminal helices pack in the reverse direction into three hydrophobic grooves on the surface of the N-terminal trimer. This thermostable subdomain displays the salient features of the core structure of the isolated gp41 subunit and thus provides a possible target for therapeutics designed selectively to block HIV-1 entry.