Biotinylated Human GDF-15 / MIC-1 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: GD5-H81Q3
Physical State:: Powder
Molecular Weight:: 16.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 0.085% TFA, 30% ACN
Immunogen:: GDF-15
Species:: Human
Uniprot:: Q99988-1
Synonyms:: Macrophage inhibitory cytokine 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental bone morphogenetic protein;Placental TGF-beta;Prostate differentiation factor
Extra Details:: Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1B Beta, tumor necrosis factor A Alpha (TNF-A Alpha), interleukin 2, and macrophage colony-stimulating factor but not interferon G Gamma, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.