GD5-H5149
Human GDF-15 / MIC-1 Protein, His Tag, low Endotoxin
Cannot supply to this region.
- SKU:
- GD5-H5149
- Additional Names:
- GDF-15|GDF15|MIC-1|MIC1|NAG-1|NRG-1|PDF|PLAB|PTGFB
- Physical State:
- Powder
- Molecular Weight:
- 14.3 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 20 mM Citric acid, 200 mM NaCl, pH3.0
- Immunogen:
- GDF-15
- Species:
- Human
- Uniprot:
- Q99988-1
- Synonyms:
- Macrophage inhibitory cytokine 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental bone morphogenetic protein;Placental TGF-beta;Prostate differentiation factor
- Extra Details:
- Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1B Beta, tumor necrosis factor A Alpha (TNF-A Alpha), interleukin 2, and macrophage colony-stimulating factor but not interferon G Gamma, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
- Shipping Conditions:
- Ambient