Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free

Cannot supply to this region.

SKU:: GA1-C52W7
Additional Names:: LRRC32 & TGF-beta 1|LRRC32&TGFB1
Physical State:: Powder
Molecular Weight:: 68.1 kDa (LRRC32) & 41.2 kDa (TGF-beta 1)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: LRRC32 & TGF-beta 1
Species:: Non-human Primate
Uniprot:: A0A2K5TJB2, A0A2K5X2X9-1
Synonyms:: transforming growth factor beta-1
Extra Details:: GARP (LRRC32) is a transmembrane protein that binds latent-TGF-B Beta1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor B Beta (TGF-B Beta). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor B Beta (TGF-B Beta), thus promoting secretion and activation of TGF-B Beta. TGF-B Beta plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-B Beta1 complexes do not activate TGF-B Beta1. However, it cannot be excluded that specific stimuli are required to trigger TGF-B Beta1 activation from complexes on the surface of these cell types.