Rhesus macaque Coagulation factor XI Protein, His Tag (Pro-form)

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SKU:: FXI-C52H3
Physical State:: Powder
Molecular Weight:: 69.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 20 mM HEPES,150 mM NaCl,pH7.5
Immunogen:: Coagulation factor XI
Species:: Non-human Primate
Extra Details:: This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality