FUS-H5144
Human FUS Protein, MBP,His Tag
Cannot supply to this region.
- SKU:
- FUS-H5144
- Physical State:
- Powder
- Molecular Weight:
- 97.0 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- PBS
- Immunogen:
- FUS
- Species:
- Human
- Uniprot:
- P35637-1
- Synonyms:
- 75 kDa DNA-pairing protein;Oncogene FUS;Oncogene TLS;POMp75;Translocated in liposarcoma protein
- Extra Details:
- FUS (RNA-binding protein FUS) is a DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. FUS plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
- Shipping Conditions:
- Ambient