Human FKBP12 / FKBP1A Protein, His Tag

Cannot supply to this region.

SKU:: FKA-H5122
Additional Names:: Calstabin-1|FKBP1|FKBP12|FKBP1A|PKC12|PPIASE|Rotamase
Physical State:: Powder
Molecular Weight:: 12.8 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM HEPES, 150 mM NaCl, pH7.5
Immunogen:: FKBP12
Species:: Human
Uniprot:: P62942-1
Synonyms:: 12 kDa FK506-binding protein;Calstabin-1;FK506-binding protein 1A;Immunophilin FKBP12;Rotamase
Extra Details:: Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.