Human FGF R3 (IIIb) / FGF R3B / CD333 Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: FGB-H5259
Additional Names:: CD333|FGF R3 (IIIb)|FGF R3B
Physical State:: Powder
Molecular Weight:: 65.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: FGF R3 (IIIb)
Species:: Human
Uniprot:: P22607-2
Extra Details:: Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc). Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCG Gamma signaling cascade.