FG9-H5254
Human FGF19 Protein, Mouse IgG2a Fc Tag
Cannot supply to this region.
- SKU:
- FG9-H5254
- Physical State:
- Powder
- Molecular Weight:
- 48.3 kda
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- FGF19
- Species:
- Human
- Uniprot:
- O95750-1
- Extra Details:
- Fibroblast Growth Factor 19 (FGF19) is a hormone belonging to the FGF family, encoded by the FGF19 gene. It is primarily synthesized and secreted in the ileum in response to bile acid absorption, acting as a ligand for the farnesoid X receptor (FXR). FGF19's core function is to exert negative feedback on hepatic bile acid synthesis by binding to the Fibroblast Growth Factor Receptor 4 (FGFR4)/Klotho-B Beta complex in the liver, thereby inhibiting cholesterol 7A Alpha-hydroxylase (CYP7A1). Additionally, it plays a role in glucose and lipid metabolism. Its mouse ortholog is FGF15, and they are often referred to collectively as FGF15/19. Altered FGF19 levels are implicated in chronic bile acid diarrhea and certain metabolic disorders.
- Shipping Conditions:
- Ambient