Biotinylated Mouse Fc gamma RIV / CD16-2 Protein, His,Avitag[TM] (HPLC & BLI verified)

Cannot supply to this region.

SKU:: FC4-M82E8
Additional Names:: CD16-2|Fc gamma RIV|Fcgr4
Physical State:: Powder
Molecular Weight:: 24.6 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Fc gamma RIV / CD16-2
Species:: Mouse
Uniprot:: A0A0B4J1G0-1
Synonyms:: CD16-2;FcgammaRIV
Extra Details:: FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma . Also acts as a receptor for the Fc region of immunoglobulin epsilon . Binds with intermediate affinity to both IgG2a and IgG2b . Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions