Mouse FAP Protein, His Tag, active dimer (MALS verified)

Cannot supply to this region.

SKU:: FAP-M52H3
Additional Names:: APCE|FAP|FAPalpha|Seprase|SIMP
Physical State:: Powder
Molecular Weight:: 87.1 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: FAP
Species:: Mouse
Uniprot:: P97321-1
Synonyms:: Dipeptidyl peptidase FAP;Fibroblast activation protein alpha;Gelatine degradation protease FAP;Integral membrane serine protease;Post-proline cleaving enzyme;Serine integral membrane protease;Surface-expressed protease
Extra Details:: FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.