FABM044-01
PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) (0.03% Proclin)
Cannot supply to this region.
- SKU:
- FABM044-01
- Application:
- Flow Cytometry
- Physical State:
- Liquid
- Storage Conditions:
- 2-8[o]C Protect from light.
- Supplier:
- ACRO Biosystems
- Reactivities:
- Mouse
- Buffer:
- PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA
- Immunogen:
- CD279
- Clone:
- AS630
- Extra Details:
- CD279, or programmed cell death protein 1 (PD-1), is a 55 kD member of the immunoglobulin superfamily with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic region. It is mainly expressed on activated T cells, B cells and myeloid cells, and negatively regulates immune responses by binding to its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), thereby inhibiting T cell proliferation and cytokine secretion. Dysregulatio of the PD-1 pathway is linked to autoimmune diseases (e.g, rheumatoid arthritis, systemic lupus erythematosus) and tumor immune escape, makin it a key target for cancer immunotherapy. The antibody PE, anti-Human CD279 (PD-1)-AS630 binds specifically to CD279, facilitating relevant research.
- Shipping Conditions:
- Blue Ice