ELL-H5595
Human Elongin B&Elongin C&VHL Heterotrimer Protein, Strep II Tag&Strep II Tag&His Tag (MALS&SPR verified)
Cannot supply to this region.
- SKU:
- ELL-H5595
- Additional Names:
- ELOB & ELOC & VHL Complex|Elongin B & Elongin C & VHL|Elongin B & Elongin C & VHL Complex
- Physical State:
- Liquid
- Molecular Weight:
- 14.5 kDa & 13.8 kDa & 25.8 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM HEPES, 200 mM NaCl, Glycerol, pH7.5
- Immunogen:
- Elongin B & Elongin C & VHL
- Species:
- Human
- Uniprot:
- P40337-2, Q15369-1, Q15370-1
- Synonyms:
- Elongin 15 kDa subunit;Elongin 18 kDa subunit;Protein G7;pVHL;RNA polymerase II transcription factor SIII subunit B;RNA polymerase II transcription factor SIII subunit C;SIII p15;SIII p18;Transcription elongation factor B polypeptide 1;Transcription elongation factor B polypeptide 2
- Extra Details:
- Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complex--a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. In this function, ELOB/ELOC serves as an adapter between substrate recognition proteins and either Cullin-2/Rbx1 (in VHL-box E3 Ubiquitin ligases) or Cullin-5/Rbx2 (in SOCS-box E3 Ubiquitin ligases). VHL is involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
- Shipping Conditions:
- Dry Ice