EF4-E5143
E. coli Elongation Factor 4 Protein, His Tag (active enzyme)
Cannot supply to this region.
- SKU:
- EF4-E5143
- Physical State:
- Liquid
- Molecular Weight:
- 68.5 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS, 0.5 M NaCl, 1 M Arginine, pH7.4
- Immunogen:
- Elongation Factor 4
- Species:
- Bacteria
- Uniprot:
- C4ZYJ2
- Synonyms:
- Ribosomal back-translocase LepA
- Extra Details:
- Elongation Factor 4 (EF4), also known as LepA , is a highly conserved GTPase translation factor present across bacteria, mitochondria, and chloroplasts. It regulates protein synthesis by interacting with the ribosome during translation elongation. Unlike canonical elongation factors (e.g., EF-G) that promote forward translocation, EF4 catalyzes back-translocation of tRNAs on the ribosome, effectively acting as a molecular 'reverse gear' to reposition tRNAs and mRNA. This unique function allows EF4 to maintain translational fidelity under stress conditions (e.g., low pH or high ionic strength) by rescuing stalled ribosomes and correcting errors in protein synthesis.
- Shipping Conditions:
- Dry Ice